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What is Alloblast?

Connective tissue originates from the mesoderm and is the most common tissue in the organism (Epithelium, Muscle, Bone, Nerve). After birth, cells differentiate and acquire a new cellular identity in the first 4 months. The treatment method based on injecting fibroblast cells obtained from mesenchymal connective tissue, derived from the foreskin of a 1-day-old newborn through a high-tech laboratory environment and using biotechnology techniques, into the desired area of the individual is called ‘REJUVENATION with ALLOBLAST CULTURE.’ Not every foreskin is suitable for this technique; approximately 400 donors’ foreskins undergo serological tests to prepare one alloblast culture. Mesenchymal Cells: Fibroblast Macrophages Fat cells Plasma cells Mast cells Pigment cells Blood Cells (Lymphocytes, Monocytes, Neutrophils, Eosinophils) Mesenchymal-origin fibroblast cells are produced in a GMP-approved zero-particle laboratory with technology systems, including critical processes to produce millions of new undifferentiated cells. The produced fibroblast cells go through the quality control processes determined by the Ministry of Health and European Standards, becoming ready for application. The patient comes to the clinic and is anesthetized with a serious topical anesthetic cream. The alloblast culture is injected into the desired area of the patient. The alloblast application is a single session. It should not be forgotten that the alloblast treatment is very different from other treatments as it contains millions of fibroblast cells producing collagen and elastin. Fibroblasts are the fundamental cells that form the connective tissue in the sublayer of the skin (producing elastin and collagen). Over time, as these cells die, the connective tissue begins to collapse, and the youthful and young appearance of the skin gradually disappears. This leads to an increase in sagging and wrinkles due to aging on the skin. Structural support is provided to the tissues under the skin, and proliferation is achieved by differentiating stem cells into the necessary cells in rejuvenation treatments.

What is a Fibroblast? What is Allogeneic Fibroblast Stem Cell Therapy?

Fibroblasts are cells that form the substructure of the skin, carrying collagen for skin repair. Fibroblasts have a critical impact on creating, regulating, and repairing the skin tissue architecture.

Fibroblasts are mesenchymal in origin and are the main group of cells responsible for the regeneration of the tissue. During tissue healing and repair, fibroblasts transform into myofibroblasts. The control of this transformation is regulated by TGF-β secreted by blood cells called platelets. They are the basic cells of the connective tissue, and their shape is flat, elongated, and oval. They can be 1-2 nucleated, and their nuclei are like lemon seeds. They have extensive cytoplasm and play very important roles in the organism like every cell. The most important of these is to form the structure in which the cells are located. This support structure between cells consists of collagen and elastin fibers, giving brightness, softness, and elasticity to the skin. The function of fibroblasts is to produce these crucial substances for the skin. Another important function of fibroblasts is to activate the organism’s wound-healing system when there is an injury on the skin.

Fibroblast growth factors;
  • They determine many functions responsible for cell proliferation and cell survival.
  • They constitute a large peptide growth factor family. They control a variety of biological functions that regulate healing by protecting cells from damage.
  • They play an important role in tissue repair and response to injury. Fibroblast growth factors known to play specific roles in the body have a unique capacity to protect against DNA damage.
  • In many skin problems and damages, such as wound healing, they play an important role in tissue repair. After tissue injury, fibroblasts rush to the areas of destruction where they will support new collagen formation and facilitate the healing process.
  • Fibroblasts’ appearance varies depending on their functions and target areas. They stand out with many successful treatment results.
  • Fibroblasts provide vital structural support for cells and have significant effects on their functions. They are the primary source of proteins that play a key role in determining the functions of cells.

What are the Advantages of Fibroblast Culture Therapy?

Due to an increase in average lifespan, people are concerned about appearing young and dynamic even in old age. The improvement in the quality of life partly achieves this. Allogeneic fibroblast stem cell therapy shows a very rapid and remarkably significant rejuvenation and improvement in dermocosmetics.

As the fibroblast activity decreases in our skin, proteins like collagen, elastin, and hyaluronic acid also decrease, resulting in fine lines and deep wrinkles, especially in mimetic areas. Studies have shown that after the age of 20, our body’s collagen capacity decreases by 1.5% each year. At the age of 40, this rate reaches about a 30% collagen loss. Particularly, fibroblasts in the sun-exposed areas of the skin break down faster due to sunlight radiation and their numbers decrease. With the progression of fibroblast loss, the skin loses its youthful appearance and firmness; the skin collapses, sags, and deep wrinkles begin to form. To eliminate these negative effects, allogeneic fibroblasts that perform their function correctly should be provided to the skin.

What are the Advantages of Allogeneic Fibroblast Culture Therapy Compared to Autologous Fibroblast Therapy?

With the alloblast culture treatment method, millions of fibroblasts with high vitality, serologically tested, and proven reliability can be easily injected into the desired area through a mesotherapeutic application in a single session, resulting in a visibly

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